Description

6-Chloro-8-Fluoro-[1,2,4]Triazolo[4,3-A]Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its fused heterocyclic structure containing chlorine and fluorine substituents. This compound is of significant commercial importance due to its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modulation. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new drugs, agrochemicals, and other specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially in oncology, central nervous system (CNS), and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the triazolopyridine scaffold offers unique biological activity.
• Material Science: Acts as a building block for creating advanced organic electronic materials, such as ligands for organic light-emitting diodes (OLEDs) or charge-transport materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tag in biochemical research due to its reactive halogen sites for further functionalization.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	6-Chloro-8-Fluoro-[1,2,4]Triazolo[4,3-A]Pyridine
CAS No.	1020253-21-7
Molecular Formula	C6H2ClFN4
Molecular Weight	184.56 g/mol
Synonyms	6-Chloro-8-fluoro-[1,2,4]triazolo[4,3-a]pyridine; 6-Chloro-8-fluoro-1,2,4-triazolo[4,3-a]pyridine; 6-Chloro-8-fluoro-s-triazolo[4,3-a]pyridine; 8-Fluoro-6-chloro-[1,2,4]triazolo[4,3-a]pyridine; [1,2,4]Triazolo[4,3-a]pyridine, 6-chloro-8-fluoro-; 1020253-21-7
EINECS	Contact for details

Quality Control

Our 6-Chloro-8-Fluoro-[1,2,4]Triazolo[4,3-A]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring traceability and consistency for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to fluoride/strong alkali conditions. Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.