Description

2-Aminoisobutyric Acid-15N, α-n-Fmoc is a stable isotope-labeled, N-Fmoc protected derivative of 2-aminoisobutyric acid, incorporating a 15N atom at the amino position. This compound is a critical building block for the synthesis of isotopically labeled peptides, enabling advanced research in proteomics, metabolic studies, and NMR spectroscopy. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs specializing in peptide synthesis and mass spectrometry.

Application

• Synthesis of 15N-labeled peptides for nuclear magnetic resonance (NMR) structural and dynamics studies.
• Preparation of internal standards for quantitative mass spectrometry (MS) in proteomic and metabolomic research.
• Biochemical tracer applications to study amino acid metabolism, protein turnover, and biosynthetic pathways.
• Solid-phase peptide synthesis (SPPS) as a protected, isotopically enriched amino acid derivative.
• Development of novel peptide-based therapeutics and diagnostics requiring isotopic labeling.
• Research in chemical biology to create probes for studying protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	2-Aminoisobutyric Acid-15N, α-n-Fmoc
CAS No.	1019641-03-2
Molecular Formula	C19H1915NNO4
Molecular Weight	313.36 g/mol (for 15N isotopologue)
Synonyms	Fmoc-Aib(15N)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-aminoisobutyric-15N acid; (15N)-2-[(9-Fluorenylmethoxycarbonyl)amino]-2-methylpropanoic acid; Fmoc-2-aminoisobutyric-15N acid; Fmoc-Aib(15N); 2-Methyl-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]propionic-15N acid; 15N-Fmoc-Aib-OH; 2-(Fmoc-amino)-2-methylpropionic-15N acid
EINECS	Contact for details

Quality Control

Our 2-Aminoisobutyric Acid-15N, α-n-Fmoc is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment. Each batch is analyzed to confirm identity, purity, and isotopic content. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and MS. We support compliance with cGMP and ICH guidelines for advanced pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N)	≥ 98 atom %
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.