Description

Esculetin is a naturally occurring coumarin derivative, also known as 6,7-dihydroxycoumarin, valued for its significant biological and pharmacological activities. This high-purity compound is essential for research and development in advanced life sciences and fine chemical synthesis. It serves as a critical intermediate and reference standard for pharmaceutical, nutraceutical, and cosmetic manufacturers seeking bioactive ingredients with antioxidant and enzyme-inhibiting properties.

Application

• Pharmaceutical Intermediate: Used in the synthesis of novel drug candidates targeting inflammation, diabetes, and oxidative stress-related conditions.
• Biochemical Research: Acts as a reference standard and key reagent in studying enzyme inhibition, particularly against tyrosinase and lipoxygenase.
• Cosmetic & Skincare Formulations: Incorporated into serums and creams for its antioxidant properties and potential skin-brightening effects.
• Nutraceutical Development: Serves as a bioactive marker compound in the standardization of herbal extracts and dietary supplements.
• Analytical Chemistry: Employed as a high-purity HPLC standard for quality control in related natural product analysis.
• Organic Synthesis: A versatile building block for synthesizing more complex coumarin-based derivatives with enhanced bioactivity.

Basic Information

Product Name	Esculetin
CAS No.	305-01-1
Molecular Formula	C9H6O4
Molecular Weight	178.14 g/mol
Synonyms	6,7-Dihydroxycoumarin; Aesculetin; Cichorigenin; Esculetol; 6,7-Dihydroxy-2H-1-benzopyran-2-one; 6,7-Dihydroxy-2H-chromen-2-one
EINECS	206-161-5

Quality Control

Our Esculetin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and related substance analysis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.