Description

n-Nitrosopiperidine is a high-purity nitrosamine compound of significant importance in chemical research and industrial synthesis. It serves as a critical intermediate and reference standard for analytical and toxicological studies, particularly in the investigation of nitrosamine formation and mitigation. This product is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and chemical manufacturing sectors who require reliable, high-quality materials for method development and impurity analysis.

Application

• Pharmaceutical Research & Impurity Analysis: Used as a reference standard and analytical marker for the detection and quantification of nitrosamine impurities (e.g., NDMA, NDEA) in active pharmaceutical ingredients (APIs) and finished drug products.
• Chemical Synthesis Intermediate: Acts as a versatile building block in organic synthesis for the preparation of more complex nitrogen-containing heterocycles and specialty chemicals.
• Toxicology & Carcinogenicity Studies: Employed in laboratory research to study the metabolic pathways, genotoxicity, and carcinogenic mechanisms of nitrosamine compounds.
• Method Development & Validation: Serves as a key calibrant in developing and validating sensitive analytical methods, such as LC-MS/MS and GC-MS, for nitrosamine testing in various matrices.
• Regulatory Compliance Testing: Supports compliance testing for global regulatory standards (e.g., FDA, EMA, ICH M7(R2)) that mandate strict control of nitrosamine impurities in pharmaceuticals.
• Material Science Research: Investigated for its properties and potential applications in polymer chemistry and materials science.

Basic Information

Product Name	n-Nitrosopiperidine
CAS No.	100-75-4
Molecular Formula	C5H10N2O
Molecular Weight	114.15 g/mol
Synonyms	1-Nitrosopiperidine; N-Nitrosopiperidine; Piperidine, 1-nitroso-; Nitrosopiperidine; NSC 7202; N-Nitrosopiperidin; N-Nitrosopiperidina; N-Nitrosopiperidinum
EINECS	202-885-1

Quality Control

Our n-Nitrosopiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity determination by chromatographic techniques. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the results against our stringent internal specifications. We support compliance with relevant guidelines for reference standards and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as a nitrosamine and being easily oxidized, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to orange liquid or crystalline mass
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.