Description

1-Boc-4-(5-Methylthiazol-2-Yl)Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core protected by a tert-butoxycarbonyl (Boc) group and substituted with a 5-methylthiazole moiety. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in the areas of kinase inhibitors and central nervous system (CNS) active compounds.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for drug discovery and development.
• Kinase Inhibitor Research: Serves as a core scaffold for the design and synthesis of small molecule inhibitors targeting various protein kinases.
• CNS Drug Development: Used in constructing pharmacophores for potential therapeutics targeting neurological disorders.
• Chemical Biology & Proteomics: Employed as a tool compound or a linker in the development of chemical probes for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific piperazine derivative.
• Academic Research: Utilized in university and institutional laboratories for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	1-Boc-4-(5-Methylthiazol-2-Yl)Piperazine
CAS No.	1019637-75-2
Molecular Formula	C13H21N3O2S
Molecular Weight	283.39 g/mol
Synonyms	tert-Butyl 4-(5-methyl-1,3-thiazol-2-yl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(5-methyl-2-thiazolyl)piperazine; 4-(5-Methylthiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(5-methylthiazol-2-yl)piperazine; 2-(1-Boc-piperazin-4-yl)-5-methylthiazole; N-Boc-4-(5-methyl-2-thiazolyl)piperazine; Piperazine, 4-(5-methyl-2-thiazolyl)-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(5-Methylthiazol-2-Yl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.