Description

4-(2,6-Difluorophenyl)Piperidine is a high-purity, versatile piperidine derivative and a key fluorinated building block in advanced organic synthesis. This compound is critical for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly due to the bioisosteric properties imparted by its difluorophenyl group. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers seeking to introduce fluorine atoms into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluorophenyl moiety enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and liquid crystals with specific electronic or optical properties.
• Chemical Biology Probes: Used to create molecular probes for studying enzyme function and receptor interactions in biological systems.

Basic Information

Product Name	4-(2,6-Difluorophenyl)Piperidine
CAS No.	1019373-70-6
Molecular Formula	C11H13F2N
Molecular Weight	197.22 g/mol
Synonyms	4-(2,6-Difluorophenyl)piperidine; 2,6-Difluoro-4-piperidinylbenzene; 1-(2,6-Difluorophenyl)piperidine-4-carboxylic acid (precursor); 4-(2,6-Difluorophenyl)piperidine hydrochloride (salt form); Piperidine, 4-(2,6-difluorophenyl)-; 1019373-70-6; 4-(2,6-Difluorophenyl)piperidine free base
EINECS	Contact for details

Quality Control

Our 4-(2,6-Difluorophenyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.