Description

1-Boc-4-(2-Amino-1-(4-Bromo-Phenyl)Ethyl)-Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core protected by a Boc (tert-butoxycarbonyl) group and a chiral aminoethyl side chain with a bromophenyl substituent. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially in CNS and oncology therapeutic areas.
• Peptidomimetic Synthesis: Used to incorporate constrained piperazine scaffolds into peptide-like molecules to enhance metabolic stability and receptor binding affinity.
• Ligand and Probe Development: Serves as a versatile precursor for creating chemical probes and high-affinity ligands for biological target validation in drug discovery.
• Custom Synthesis Building Block: Employed in contract research and manufacturing (CRO/CMO) for the custom synthesis of complex, proprietary molecules for clients.
• Academic Research: Utilized in university and institutional labs for methodological studies in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-Boc-4-(2-Amino-1-(4-Bromo-Phenyl)Ethyl)-Piperazine
CAS No.	1018544-60-9
Molecular Formula	C17H26BrN3O2
Molecular Weight	384.31 g/mol
Synonyms	1-Boc-4-[2-Amino-1-(4-bromophenyl)ethyl]piperazine; tert-Butyl 4-[2-amino-1-(4-bromophenyl)ethyl]piperazine-1-carboxylate; 4-Bromo-α-(2-aminoethyl)benzenemethanol 1-Boc-piperazine derivative; 1-(tert-Butoxycarbonyl)-4-[2-amino-1-(4-bromophenyl)ethyl]piperazine; (R/S)-1-Boc-4-(2-Amino-1-(4-Bromo-Phenyl)Ethyl)-Piperazine; Piperazine, 1-Boc-4-(2-amino-1-(4-bromophenyl)ethyl)-; BOC-4-(2-Amino-1-(4-Bromo-Phenyl)Ethyl)-Piperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(2-Amino-1-(4-Bromo-Phenyl)Ethyl)-Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral assay, and identity confirmation is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.