Description

2-Chloro-1-[4-(4-Fluoro-Benzoyl)-Piperazin-1-Yl]-Ethanone is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine-based structure with a reactive chloroacetyl group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of targeted therapeutic agents. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel drug candidates, especially within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the design, synthesis, and screening of new chemical entities with potential biological activity.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of protease inhibitors and other enzyme-targeting therapeutics.
• Kinase Inhibitor Development: Employed in the construction of kinase inhibitor scaffolds for targeted cancer therapies.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological pathways and protein functions.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	2-Chloro-1-[4-(4-Fluoro-Benzoyl)-Piperazin-1-Yl]-Ethanone
CAS No.	1018525-90-0
Molecular Formula	C13H14ClFN2O2
Molecular Weight	284.71 g/mol
Synonyms	1-(4-(4-Fluorobenzoyl)piperazin-1-yl)-2-chloroethan-1-one; 2-Chloro-1-(4-(4-fluorobenzoyl)piperazin-1-yl)ethanone; 4-(4-Fluorobenzoyl)-1-(chloroacetyl)piperazine; 1-(4-(4-Fluorobenzoyl)piperazinyl)-2-chloroethanone; 2-Chloro-1-(4-(4-fluorobenzoyl)-1-piperazinyl)ethanone; N-(4-Fluorobenzoyl)-N'-(chloroacetyl)piperazine; 1018525-90-0
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-[4-(4-Fluoro-Benzoyl)-Piperazin-1-Yl]-Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.