Description

1-Boc-4-(2-Amino-1-(4-Fluoro-Phenyl)Ethyl)-Piperazine is a high-purity, protected piperazine derivative serving as a critical building block in modern organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex, biologically active molecules, particularly within the pharmaceutical sector. It is primarily needed by research chemists and process development scientists in pharmaceutical, agrochemical, and fine chemical industries for constructing novel drug candidates and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors, where the piperazine scaffold is a common pharmacophore.
• Kinase Inhibitor Synthesis: Serves as a building block for creating potential kinase inhibitors, a major class of targeted cancer therapies.
• Peptidomimetic Chemistry: Employed in the design and synthesis of peptidomimetics, which mimic peptides but with enhanced stability and bioavailability.
• Agrochemical Research: Acts as an intermediate in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific chiral or functionalized intermediates.
• Academic & Institutional Research: Used in university and institutional labs for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Boc-4-(2-Amino-1-(4-Fluoro-Phenyl)Ethyl)-Piperazine
CAS No.	1018297-04-5
Molecular Formula	C17H26FN3O2
Molecular Weight	323.41 g/mol
Synonyms	1-Boc-4-[2-Amino-1-(4-fluorophenyl)ethyl]piperazine; tert-Butyl 4-[2-amino-1-(4-fluorophenyl)ethyl]piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[2-amino-1-(4-fluorophenyl)ethyl]piperazine; N-Boc-4-(2-amino-1-(4-fluorophenyl)ethyl)piperazine; 4-(2-Amino-1-(4-fluorophenyl)ethyl)piperazine-1-carboxylic acid tert-butyl ester; 1018297-04-5; Boc-Pip(4-F-Ph-CH(NH2)CH2)-OH (common abbreviation)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, chiral purity (where applicable), and impurity profiles are available upon request. We adhere to cGMP guidelines for the manufacture of pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for specified enantiomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.