Description

tert-Butyl 4-[(5-Bromo-3-Pyridinyl)Carbonyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific bromopyridine and piperazinecarboxylate functional groups. This compound is critical for research and development in medicinal chemistry, serving as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, particularly in kinase inhibitor programs.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• API Synthesis: Serves as a building block for constructing the core pharmacophore in potential therapeutic molecules.
• Chemical Biology Probes: Employed in the development of labeled compounds for target identification and validation studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic methodology and novel heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 4-[(5-Bromo-3-Pyridinyl)Carbonyl]Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	1017782-72-7
Molecular Formula	C15H20BrN3O3
Molecular Weight	370.24 g/mol
Synonyms	1-Boc-4-(5-bromonicotinoyl)piperazine; tert-Butyl 4-(5-bromonicotinoyl)piperazine-1-carboxylate; 4-(5-Bromo-3-pyridinyl)carbonyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(5-bromonicotinoyl)piperazine; Boc-4-(5-bromonicotinoyl)piperazine; 1017782-72-7; 5-Bromo-N-(1-Boc-piperazin-4-yl)nicotinamide
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-[(5-Bromo-3-Pyridinyl)Carbonyl]Tetrahydro-1(2H)-Pyrazinecarboxylate adheres to stringent internal quality standards, ensuring batch-to-batch consistency suitable for research and development applications. All materials are fully characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.