Description

tert-Butyl 4-[(5-Bromo-2-Thienyl)Carbonyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is a high-value, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure incorporating both thiophene and piperazine motifs. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used as a sophisticated building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: Serves as a core scaffold for the research and development of protease inhibitors, leveraging the piperazine moiety.
• CNS Drug Discovery: Employed in the synthesis of compounds targeting central nervous system (CNS) disorders due to the potential blood-brain barrier permeability of related structures.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	tert-Butyl 4-[(5-Bromo-2-Thienyl)Carbonyl]Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	1017782-71-6
Molecular Formula	C14H19BrN2O3S
Molecular Weight	375.28 g/mol
Synonyms	1-Boc-4-(5-bromothiophene-2-carbonyl)piperazine; tert-Butyl 4-(5-bromothiophene-2-carbonyl)piperazine-1-carboxylate; 4-(5-Bromo-2-thienylcarbonyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(5-bromothiophene-2-carbonyl)piperazine; 4-(5-Bromothiophene-2-carbonyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(5-bromothiophene-2-carbonyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[(5-Bromo-2-Thienyl)Carbonyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity by HPLC, identity confirmation (NMR, IR), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.