Description

2-Chloro-6-Isopropoxypyrazine is a high-purity, versatile heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its bifunctional reactivity, offering both a halogenated site for cross-coupling and an alkoxy group for further functionalization, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyrazine core for bioactivity.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or light-emitting components.
• Chemical Biology Probes: Utilized to create tagged molecules or probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	2-Chloro-6-Isopropoxypyrazine
CAS No.	1016698-79-5
Molecular Formula	C7H9ClN2O
Molecular Weight	172.61 g/mol
Synonyms	6-Isopropoxy-2-chloropyrazine; 2-Chloro-6-(1-methylethoxy)pyrazine; 2-Chloro-6-(propan-2-yloxy)pyrazine; Pyrazine, 2-chloro-6-(1-methylethoxy)-; 2-Chloro-6-isopropoxy-pyrazine; 2-Chloro-6-(isopropyloxy)pyrazine; 1016698-79-5
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Isopropoxypyrazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, GC for residual solvents, and NMR/IR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results. We support development and commercial projects requiring compliance with various pharmacopeial or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and prolonged exposure to air; for long-term storage, consider an inert atmosphere. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.