Description

5H-Pyrrolo[2,3-B]Pyrazine-6-Carboxylic Acid is a high-purity heterocyclic carboxylic acid building block of significant importance in modern pharmaceutical research and development. Its core value lies in its role as a critical intermediate for synthesizing novel, complex molecules, particularly in the fields of oncology and kinase inhibition. This compound is essential for medicinal chemists and process development scientists working in pharmaceutical, biotechnology, and advanced fine chemical sectors who require reliable, high-quality building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and targeted cancer therapies.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the pyrrolopyrazine core.
• Process Chemistry & Scale-Up: Serves as a starting material or advanced intermediate for the development of robust, scalable synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Bioconjugation & Probe Development: The carboxylic acid functional group enables conjugation to other molecules, making it useful for creating chemical probes, diagnostics, or antibody-drug conjugates (ADCs).
• Academic & Institutional Research: Employed in universities and research institutes for fundamental studies in heterocyclic chemistry and the discovery of new bioactive compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and niche APIs for clinical trials.

Basic Information

Product Name	5H-Pyrrolo[2,3-B]Pyrazine-6-Carboxylic Acid
CAS No.	1016241-56-7
Molecular Formula	C7H5N3O2
Molecular Weight	163.14 g/mol
Synonyms	5H-Pyrrolo[2,3-b]pyrazine-6-carboxylic acid; 6-Carboxy-5H-pyrrolo[2,3-b]pyrazine; 1H-Pyrrolo[2,3-b]pyrazine-6-carboxylic acid (tautomer); Pyrrolo[2,3-b]pyrazine-6-carboxylic acid; 5H-Pyrrolo[2,3-b]pyrazine-6-carboxylic acid, CAS 1016241-56-7; 6-Pyrrolo[2,3-b]pyrazinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5H-Pyrrolo[2,3-B]Pyrazine-6-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch and supplied upon request. Our quality systems are designed to support regulatory filings, and we can supply material that meets the standards required for non-GMP and GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.