Description

2-(Trifluoromethyl)-5,6,7,8-Tetrahydro[1,2,4]Triazolo[1,5-A]Pyrazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with significant value in modern drug discovery. This compound is a key synthetic building block prized for its unique trifluoromethyl-substituted triazolopyrazine core, which is instrumental in modulating the pharmacokinetic and binding properties of target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical studies.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries via parallel and combinatorial synthesis to explore structure-activity relationships (SAR).
• CNS Drug Development: Employed in the research of potential therapeutics for neurological disorders, leveraging the triazolopyrazine moiety's affinity for relevant biological targets.
• Oncology Research: Acts as a building block for novel small-molecule inhibitors targeting specific kinases or other proteins involved in cancer pathways.
• Agrochemical Research: Potential use in the synthesis of new crop protection agents, where the trifluoromethyl group can enhance biological activity and stability.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	2-(Trifluoromethyl)-5,6,7,8-Tetrahydro[1,2,4]Triazolo[1,5-A]Pyrazine Hydrochloride
CAS No.	1013905-12-8
Molecular Formula	C7H10ClF3N4
Molecular Weight	242.63 g/mol
Synonyms	2-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine hydrochloride; 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[1,5-a]pyrazine HCl; 1013905-12-8; 2-Trifluoromethyl-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazine hydrochloride; Triazolopyrazine hydrochloride derivative; 5,6,7,8-Tetrahydro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazine hydrochloride
EINECS	Contact for details

Quality Control

Our production of 2-(Trifluoromethyl)-5,6,7,8-Tetrahydro[1,2,4]Triazolo[1,5-A]Pyrazine Hydrochloride adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure compliance with research and development grade specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.