Description

2-Hydroxy-4-Pentynoic Acid is a versatile bifunctional organic compound featuring both a terminal alkyne and a carboxylic acid group, making it a valuable building block in synthetic organic chemistry. Its unique structure enables it to serve as a key intermediate for the synthesis of complex molecules through reactions like Sonogashira coupling and click chemistry. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality raw materials for their development and production processes.

Application

• Pharmaceutical Intermediate: A crucial synthon for constructing active pharmaceutical ingredients (APIs), particularly those requiring alkyne functionalization for further derivatization or conjugation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators that incorporate acetylene motifs.
• Click Chemistry Reagent: Serves as a precursor for Huisgen cycloaddition (azide-alkyne click chemistry) to create triazole-linked polymers, dendrimers, and bioconjugates.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis and polymerization reactions.
• Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers and resins with tailored properties.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological processes and protein interactions.

Basic Information

Product Name	2-Hydroxy-4-Pentynoic Acid
CAS No.	1013026-68-0
Molecular Formula	C5H6O3
Molecular Weight	114.10 g/mol
Synonyms	4-Pentynoic acid, 2-hydroxy-; 2-Hydroxypent-4-ynoic acid; 4-Pentyn-2-ol-1-carboxylic acid; 2-Hydroxy-4-pentynoate; Terminal alkyne carboxylic acid; Propargylic hydroxy acid; 2-Hydroxy-4-pentynoic acid (CAS 1013026-68-0)
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-Pentynoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to verify identity, potency, and impurity profiles. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material is suitable for demanding research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.