Description

(S)-tert-Butyl 3-(Piperazin-1-Yl) Pyrrolidine-1-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. Its core utility lies in providing a structurally defined, nitrogen-rich scaffold for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. This compound is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical synthesis who require reliable, high-quality intermediates to accelerate drug discovery and scale-up processes. CAS No. 1010446-31-7.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting neurological receptors and kinases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its piperazine-pyrrolidine hybrid structure.
• API Development: Serves as a critical building block in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Utilized in chiral pool synthesis and for introducing stereochemical complexity in organic molecules.
• Ligand and Catalyst Precursor: Can be modified to create novel ligands for catalysis or molecular recognition applications.
• Chemical Biology Probes: Employed in the development of tool compounds for probing biological pathways and protein function.

Basic Information

Product Name	(S)-tert-Butyl 3-(Piperazin-1-Yl) Pyrrolidine-1-Carboxylate
CAS No.	1010446-31-7
Molecular Formula	C13H25N3O2
Molecular Weight	255.36 g/mol
Synonyms	1-Boc-3-(piperazin-1-yl)-(S)-pyrrolidine; (S)-1-(tert-Butoxycarbonyl)-3-(piperazin-1-yl)pyrrolidine; tert-Butyl (3S)-3-(piperazin-1-yl)pyrrolidine-1-carboxylate; (S)-1-N-Boc-3-(1-piperazinyl)pyrrolidine; (S)-3-(Piperazin-1-yl)-1-(tert-butoxycarbonyl)pyrrolidine; (S)-N-Boc-3-piperazin-1-yl-pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 3-(Piperazin-1-Yl) Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with stringent internal specifications suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.