Description

1-tert-Butyl 3-Methyl (3S,6R)-6-Methylpiperidine-1,3-Dicarboxylate is a high-purity, stereochemically defined chiral piperidine derivative used as a critical building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, particularly for central nervous system (CNS) and antiviral drugs.
• Agrochemical Synthesis: Used in the development of advanced, stereoselective pesticides and herbicides where specific chirality impacts biological activity.
• Catalyst & Ligand Preparation: Serves as a precursor for synthesizing chiral catalysts and ligands used in asymmetric synthesis.
• Academic & Industrial Research: A valuable reagent for methodological studies in organic chemistry, including novel ring-forming and functionalization reactions.
• Custom Synthesis Building Block: Employed in contract research and manufacturing (CRO/CMO) for producing custom-designed molecules for clients.
• Material Science: Potential use as a monomer or additive in the synthesis of specialized polymers with unique properties.

Basic Information

Product Name	1-tert-Butyl 3-Methyl (3S,6R)-6-Methylpiperidine-1,3-Dicarboxylate
CAS No.	1009376-98-0
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	(3S,6R)-1-(tert-Butoxycarbonyl)-6-methylpiperidine-3-carboxylic acid methyl ester; Methyl (3S,6R)-1-Boc-6-methylpiperidine-3-carboxylate; (3S,6R)-1-Boc-6-methyl-3-piperidinecarboxylic acid methyl ester; tert-Butyl (3S,6R)-3-(methoxycarbonyl)-6-methylpiperidine-1-carboxylate; (3S,6R)-6-Methyl-1-Boc-piperidine-3-carboxylic acid methyl ester; Boc-(3S,6R)-MePip(3-COOMe)-OH; (3S,6R)-Boc-6-methylnipecotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 1-tert-Butyl 3-Methyl (3S,6R)-6-Methylpiperidine-1,3-Dicarboxylate adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.