Description

1-tert-Butyl 3-Methyl (3S,4R)-Rel-4-Methylpiperidine-1,3-Dicarboxylate is a high-purity, stereochemically defined piperidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound is essential for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, where precise stereochemistry is paramount for biological activity and process reliability. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex molecules for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries to explore structure-activity relationships (SAR).
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial-scale production of target molecules.
• Asymmetric Synthesis: Serves as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers.
• Fine Chemical Production: Used in the manufacture of specialty chemicals requiring high enantiomeric purity.
• Academic Research: A valuable reagent for methodological studies in organic synthesis and catalysis at universities and R&D labs.

Basic Information

Product Name	1-tert-Butyl 3-Methyl (3S,4R)-Rel-4-Methylpiperidine-1,3-Dicarboxylate
CAS No.	1009376-54-8
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	(3S,4R)-1-(tert-Butoxycarbonyl)-4-methylpiperidine-3-carboxylic acid methyl ester; rel-(3S,4R)-1-Boc-4-methylpiperidine-3-carboxylic acid methyl ester; Methyl (3S,4R)-1-Boc-4-methylpiperidine-3-carboxylate; 1-Boc-3-methyl (3S,4R)-4-methylpiperidine-1,3-dicarboxylate; tert-Butyl (3S,4R)-3-(methoxycarbonyl)-4-methylpiperidine-1-carboxylate; (3S,4R)-4-Methyl-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-methyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques (HPLC, GC, NMR) to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing specific batch results are available upon request. We adhere to a quality management system suitable for supplying materials for research and development under cGMP-like controls where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.