Description

1-tert-Butyl 3-Methyl (3R,4R)-Rel-4-Methylpiperidine-1,3-Dicarboxylate is a high-purity, stereochemically defined chiral piperidine derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a rigid, functionalized scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the research and development of novel, stereospecific pesticides and herbicides where the specific (3R,4R) configuration can influence biological activity.
• Catalyst and Ligand Development: Serves as a precursor for creating novel chiral catalysts and ligands used in asymmetric synthesis to induce enantioselectivity.
• Academic & Industrial R&D: Employed in methodological studies and process chemistry for constructing complex nitrogen-containing heterocycles.
• Fine Chemical Production: Integral to the multi-step synthesis of high-value specialty chemicals and flavors & fragrances requiring specific stereochemistry.

Basic Information

Product Name	1-tert-Butyl 3-Methyl (3R,4R)-Rel-4-Methylpiperidine-1,3-Dicarboxylate
CAS No.	1009376-53-7
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	(3R,4R)-1-(tert-Butoxycarbonyl)-4-methylpiperidine-3-carboxylic acid methyl ester; Methyl (3R,4R)-1-Boc-4-methylpiperidine-3-carboxylate; (3R,4R)-1-Boc-4-methyl-3-piperidinecarboxylic acid methyl ester; (3R,4R)-4-Methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic acid methyl ester; rel-(3R,4R)-1-tert-Butyl 3-methyl 4-methylpiperidine-1,3-dicarboxylate; (3R,4R)-1-Boc-4-methylpipecolic acid methyl ester; BOC-(3R,4R)-4-methylpipecolic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 1-tert-Butyl 3-Methyl (3R,4R)-Rel-4-Methylpiperidine-1,3-Dicarboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical characterization, including chiral purity verification, to meet the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.