Description

N,o-Dimethyl-Naltrexone Bromide is a specialized pharmaceutical intermediate and research chemical. This compound is of significant interest for its role in the synthesis and development of opioid receptor antagonists and related therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in advanced medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel opioid antagonists and related pharmacologically active compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore modifications of the naltrexone scaffold.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Biochemical Research: Employed in vitro studies to investigate interactions with opioid receptor subtypes.
• Process Development: Utilized in scaling up and optimizing synthetic routes for next-generation therapeutic candidates.

Basic Information

Item	Detail
Product Name	N,o-Dimethyl-Naltrexone Bromide
CAS No.	1005410-37-6
Molecular Formula	C23H30BrNO4
Molecular Weight	464.40 g/mol
Synonyms	17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-6-methoxy-6α-methylmorphinan-7-one N,o-Dimethyl Bromide; Naltrexone N,o-Dimethyl Bromide Derivative; 6β-Naltrexol Methyl Bromide Derivative; Noroxymorphone N,o-Dimethyl Bromide Analog
EINECS	Contact for details

Quality Control

Our N,o-Dimethyl-Naltrexone Bromide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets high-purity standards suitable for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.