Description

2-Amino-3-Ethynylpyrazine is a specialized heterocyclic building block featuring both an amino and an ethynyl functional group on a pyrazine core. This unique bifunctional structure makes it a highly valuable intermediate for constructing complex molecular architectures in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for applications in medicinal chemistry, particularly in the synthesis of novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and other targeted therapy research.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, leveraging its heterocyclic structure for biological activity.
• Material Science Research: Serves as a monomer or precursor in the development of conductive polymers and advanced organic electronic materials.
• Chemical Biology & Proteomics: Utilized as a click chemistry handle (via the ethynyl group) for bioconjugation, labeling proteins, or developing chemical probes.
• Ligand Synthesis in Catalysis: Employed to create novel nitrogen-containing ligands for transition metal catalysts used in cross-coupling and other organic transformations.

Basic Information

Product Name	2-Amino-3-Ethynylpyrazine
CAS No.	1005349-13-2
Molecular Formula	C6H5N3
Molecular Weight	119.12 g/mol
Synonyms	3-Ethynylpyrazin-2-amine; 2-Pyrazinamine, 3-ethynyl-; 3-Ethynyl-2-pyrazinamine; 2-Amino-3-ethynylpyrazine; Pyrazine, 2-amino-3-ethynyl-
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Ethynylpyrazine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.