Description

2-Pyrazinamine, 3-[2-(Trimethylsilyl)ethynyl]- is a specialized pyrazine derivative featuring a trimethylsilyl-protected acetylene moiety, making it a valuable building block in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise molecular architecture for the development of novel materials and active pharmaceutical ingredients (APIs). It is primarily utilized by the pharmaceutical, agrochemical, and materials science industries for applications in medicinal chemistry, ligand synthesis, and as a precursor for heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and antiviral agent synthesis.
• Agrochemical Research: Used in the creation of novel pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Material Science: Acts as a precursor for organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its conjugated system and functional handle.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Sonogashira) and click chemistry, where the protected alkyne group is a crucial functional unit.
• Ligand and Catalyst Development: Utilized to create novel ligands for transition metal catalysis in asymmetric synthesis.

Basic Information

Product Name	2-Pyrazinamine, 3-[2-(Trimethylsilyl)ethynyl]-
CAS No.	1005349-12-1
Molecular Formula	C9H13N3Si
Molecular Weight	191.31 g/mol
Synonyms	3-[(Trimethylsilyl)ethynyl]pyrazin-2-amine; 3-(2-Trimethylsilylethynyl)-2-pyrazinamine; 3-Ethynyl-2-pyrazinamine, trimethylsilyl derivative; TMS-Ethynyl Pyrazinamine; 2-Amino-3-[(trimethylsilyl)ethynyl]pyrazine; 3-(Trimethylsilylethynyl)pyrazin-2-amine; 1005349-12-1
EINECS	Contact for details

Quality Control

Our 2-Pyrazinamine, 3-[2-(trimethylsilyl)ethynyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.