Description

4-(4-(Trifluoromethoxy)Phenyl)Piperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and research chemical of significant synthetic utility. Its core value lies in the trifluoromethoxy-phenylpiperidine scaffold, a privileged structure known for imparting favorable pharmacokinetic properties and metabolic stability to target molecules. This compound is essential for medicinal chemistry research and development, particularly for organizations engaged in the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and psychiatric disorder research.
• Medicinal Chemistry R&D: Used for structure-activity relationship (SAR) studies and lead optimization due to its piperidine and trifluoromethoxy motifs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a critical precursor in multi-step synthetic routes for potential APIs.
• Biochemical Research: Employed as a reference standard or ligand in pharmacological assays and receptor binding studies.
• Agrochemical Research: Potential intermediate for developing advanced crop protection agents with enhanced activity.
• Material Science: Exploration of specialty chemicals and advanced materials incorporating fluorine and aromatic systems.

Basic Information

Product Name	4-(4-(Trifluoromethoxy)Phenyl)Piperidine Hydrochloride
CAS No.	1004618-85-2
Molecular Formula	C12H14F3NO·HCl
Molecular Weight	281.70 g/mol (Free base: 245.24 g/mol)
Synonyms	4-[4-(Trifluoromethoxy)phenyl]piperidine hydrochloride; 1-[4-(Trifluoromethoxy)phenyl]-4-piperidinol hydrochloride (tautomer); 4-(4-Trifluoromethoxyphenyl)piperidine HCl; 4-Piperidinyl-4'-(trifluoromethoxy)benzene hydrochloride; 1004618-85-2; 4-(α,α,α-Trifluoro-p-tolyl)piperidine hydrochloride; 4-(4-Trifluoromethoxyphenyl)piperidine monohydrochloride
EINECS	Contact for details

Quality Control

Our 4-(4-(Trifluoromethoxy)Phenyl)Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.