Description

14,15-Leukotriene E4 is a specialized eicosanoid metabolite derived from the lipoxygenase pathway, playing a significant role in inflammatory and immune response signaling. This high-purity reference standard is critical for researchers and developers requiring precise analytical and biological benchmarks. It is essential for advanced life science research, pharmaceutical development, and diagnostic applications where accurate quantification of leukotriene pathways is necessary.

Application

• Biomedical Research: Used as a critical reference standard in studies investigating inflammatory diseases, asthma, and allergic responses.
• Pharmaceutical R&D: Serves as a key metabolite for drug discovery programs targeting leukotriene receptors and pathway inhibitors.
• Clinical Diagnostics: Employed as a calibration standard in LC-MS/MS and ELISA kits for the quantitative analysis of leukotriene levels in biological samples.
• Metabolomics: A vital component in lipidomic profiling to understand eicosanoid metabolism and its role in various physiological and pathological states.
• Academic Research: Facilitates fundamental biochemical and pharmacological studies in university and institutional laboratories.
• Quality Control: Acts as a system suitability standard in analytical method development and validation within QC laboratories.

Basic Information

Product Name	14,15-Leukotriene E4
CAS No.	1000852-57-2
Molecular Formula	C23H37NO7S
Molecular Weight	471.60 g/mol
Synonyms	14,15-LTE4; 14,15-Leukotriene E4; (5S,6R,14R,15S)-14,15-Dihydroxy-6-[(E,7S,9E,11Z,14Z)-7-hydroxy-9,11,14-hexadecatrienoylamino]-5-(sulfooxy)icosanoic acid; 14,15-Dihydroxy-6-(7-hydroxy-9,11,14-hexadecatrienoylamino)-5-(sulfooxy)icosanoic acid; 14,15-DH-6-(7-HHDA)-5-S-icosanoic acid; 14,15-LTE4; Leukotriene E4 metabolite
EINECS	Contact for details

Quality Control

Our 14,15-Leukotriene E4 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry guidelines to support your regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be sealed under vacuum or nitrogen after each use and allowed to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in ethanol, methanol; sparingly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.