Description

Tak875 CAS NO 1000413-72-8 is a high-purity, non-peptidic GPR40 agonist, also known as TAK-875 or fasiglifam, developed as a potential therapeutic agent. This compound is significant for its role in modulating insulin secretion in a glucose-dependent manner, offering a targeted mechanism for metabolic regulation. It is primarily needed by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in diabetes research, drug discovery, and metabolic disease studies.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel Type 2 diabetes therapies.
• Mechanistic Studies: Used in preclinical research to investigate the pharmacology and signaling pathways of the GPR40 (FFAR1) receptor.
• Biochemical Assay Development: Employed as a tool compound for screening and validating assays targeting G-protein coupled receptors (GPCRs) involved in glucose homeostasis.
• Academic Research: Facilitates studies in universities and research institutes focusing on insulin secretion, pancreatic β-cell function, and new treatment modalities for metabolic disorders.
• Contract Manufacturing: Supplied as a key building block for the cGMP synthesis of potential drug candidates under development.

Basic Information

Product Name	Tak875
CAS No.	1000413-72-8
Molecular Formula	C26H21ClO4S
Molecular Weight	464.96 g/mol
Synonyms	Fasiglifam; TAK-875; (3S)-6-({2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-carboxylic acid; GPR40 agonist TAK-875; 1-Benzofuran-3-carboxylic acid, 6-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-, (3S)-; AMG 837 (related compound); GPR40/FFAR1 agonist.
EINECS	Contact for details

Quality Control

Our Tak875 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards, and custom synthesis under cGMP guidelines can be supported for advanced development phases.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.