Description

4H-1-Benzopyran-4-One, 2-[2-Chloro-4-(Trifluoromethyl)Phenyl]-5,7-Dihydroxy-8-[(2R,3S)-2-(Hydroxymethyl)-1-Methyl-3-Pyrrolidinyl]-, Hydrochloride (1:1) is a high-purity, complex organic compound with a defined stereochemistry, supplied as a hydrochloride salt for enhanced stability and handling. This compound is a valuable advanced pharmaceutical intermediate or reference standard critical for research and development in medicinal chemistry. It is primarily sought by pharmaceutical R&D teams and contract research organizations (CROs) working on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for complex small-molecule drugs.
• Medicinal Chemistry Research: Used as a core scaffold or precursor in structure-activity relationship (SAR) studies and lead optimization programs.
• Analytical Reference Standard: Employed as a high-purity standard for method development, validation, and quality control (HPLC, LC-MS) in analytical laboratories.
• Biochemical Research: May be utilized in biochemical assays to study enzyme inhibition or receptor binding activities, given its complex heterocyclic structure.
• Process Development: Acts as a critical material for scaling up synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	4H-1-Benzopyran-4-One, 2-[2-Chloro-4-(Trifluoromethyl)Phenyl]-5,7-Dihydroxy-8-[(2R,3S)-2-(Hydroxymethyl)-1-Methyl-3-Pyrrolidinyl]-, Hydrochloride (1:1)
CAS No.	1000023-05-1
Molecular Formula	C23H22ClF3NO6 • HCl
Molecular Weight	524.78 g/mol (Free base: 488.87 g/mol)
Synonyms	2-[2-Chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one hydrochloride; 8-[(2R,3S)-2-(Hydroxymethyl)-1-methyl-3-pyrrolidinyl]-2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-4H-chromen-4-one hydrochloride; (2R,3S)-8-(2-(Hydroxymethyl)-1-methylpyrrolidin-3-yl)-2-(2-chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxychromen-4-one hydrochloride; Complex Flavonoid Derivative Hydrochloride Salt. Contact for additional trade names or abbreviations.
EINECS	Contact for details

Quality Control

Our 4H-1-Benzopyran-4-One derivative hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral methods for stereochemical confirmation, and identity verification by IR and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.