Description

2-Pyrimidinamine, 4-(4-Fluoro-1-Naphthalenyl)-6-(1-Methylethyl)-, Maleate (CAS 199864-88-5) is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. This compound is a critical building block in the synthesis of next-generation antiviral and antiretroviral active pharmaceutical ingredients (APIs). It is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutics targeting viral infections.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of advanced non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral drug discovery and manufacturing.
• Antiretroviral API Synthesis: Used in the production chain for active pharmaceutical ingredients targeting HIV and other retroviruses.
• Biochemical Research: Serves as a reference standard and a crucial reagent in virology and medicinal chemistry research programs.
• Process Development: Employed in scaling up and optimizing synthetic routes for new chemical entities (NCEs) in preclinical and clinical development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of antiviral drugs.

Basic Information

Product Name	2-Pyrimidinamine, 4-(4-Fluoro-1-Naphthalenyl)-6-(1-Methylethyl)-, Maleate
CAS No.	199864-88-5
Molecular Formula	C21H20FN3O4
Molecular Weight	397.40 g/mol
Synonyms	4-(4-Fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine maleate; 4-(4-Fluoro-1-naphthyl)-6-(1-methylethyl)-2-pyrimidinamine maleate; 4-(4-Fluoronaphthalen-1-yl)-6-(propan-2-yl)pyrimidin-2-amine maleate; 2-Amino-4-(4-fluoro-1-naphthyl)-6-isopropylpyrimidine maleate; NNRTI Intermediate Maleate Salt; CAS 199864-88-5
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory submissions. Specifications can be tailored to meet specific cGMP or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.