Description

tert-Butyl 4-(Prop-2-Ynyl)Piperazine-1-Carboxylate is a high-purity, protected piperazine derivative featuring a terminal alkyne functional group, making it a versatile and critical building block in advanced organic synthesis. Its primary value lies in enabling efficient, modular construction of complex molecules through click chemistry and other coupling reactions. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Click Chemistry Reagent: The terminal alkyne moiety enables efficient Huisgen 1,3-dipolar cycloaddition reactions with azides, a cornerstone of bioconjugation and polymer chemistry.
• Ligand and Catalyst Development: Used to construct complex piperazine-based ligands for catalysis and metal-organic frameworks (MOFs).
• Agrochemical Synthesis: Acts as a building block for developing novel herbicides, fungicides, and plant growth regulators.
• Peptidomimetic & PROTAC Synthesis: The Boc-protected piperazine scaffold is integral for creating peptide mimics and Proteolysis Targeting Chimeras (PROTACs).
• Material Science Research: Employed in the development of specialty polymers and functionalized surfaces with tailored properties.

Basic Information

Item	Details
Product Name	tert-Butyl 4-(Prop-2-Ynyl)Piperazine-1-Carboxylate
CAS No.	199538-99-3
Molecular Formula	C12H20N2O2
Molecular Weight	224.30 g/mol
Synonyms	1-Boc-4-propargylpiperazine; N-Boc-4-Propargylpiperazine; tert-Butyl 4-(2-Propynyl)-1-piperazinecarboxylate; 4-(Prop-2-yn-1-yl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(prop-2-yn-1-yl)piperazine; Boc-4-Propargylpiperazine; 199538-99-3; 4-Propargyl-1-piperazinecarboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Prop-2-Ynyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.