Description

Balaglitazone is a high-purity, synthetic thiazolidinedione derivative with significant research and development interest. This compound is a potent and selective agonist for the peroxisome proliferator-activated receptor gamma (PPARγ), a key regulator of glucose and lipid metabolism. It is primarily utilized by pharmaceutical R&D organizations and academic institutions engaged in metabolic disease research, specifically for investigating novel therapeutic pathways for type 2 diabetes and related metabolic syndromes.

Application

• Pharmaceutical Research & Development: As a reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anti-diabetic drugs.
• Mechanistic Studies: For in vitro and in vivo research to elucidate the role of PPARγ activation in insulin sensitization, adipocyte differentiation, and inflammatory pathways.
• Biochemical Assay Development: Used as a ligand in high-throughput screening (HTS) assays and binding studies to discover and characterize new PPARγ modulators.
• Preclinical Pharmacology: Serves as a key tool compound in animal models of diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD) to evaluate therapeutic efficacy and safety profiles.
• Metabolic Disorder Research: Investigation into its effects on glucose homeostasis, lipid metabolism, and potential cardiometabolic benefits beyond glycemic control.
• Chemical Synthesis: Acts as a sophisticated building block or precursor for the synthesis of novel thiazolidinedione analogs with improved pharmacological properties.

Basic Information

Product Name	Balaglitazone
CAS No.	199113-98-9
Molecular Formula	C₁₉H₂₀N₂O₃S
Molecular Weight	356.44 g/mol
Synonyms	Balaglitazone; (RS)-5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione; DRF 2593; NN 2344; (+/-)-Balaglitazone; rac-Balaglitazone; 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
EINECS	Contact for details

Quality Control

Our Balaglitazone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.