Description

Racemic-(1R,4R,5S)-tert-Butyl 5-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a rigid bicyclic scaffold with a protected amine and a hydroxyl group. This compound is a critical chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in neurology and virology research. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and contract manufacturing organizations (CMOs) seeking to develop novel therapeutic agents with high stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates targeting neurological disorders.
• Protease Inhibitor Development: Used in the research and production of antiviral agents, particularly for hepatitis C and HIV.
• Neurological Drug Synthesis: Serves as a precursor in the manufacture of medications for pain management and neurodegenerative diseases.
• Asymmetric Catalysis Ligand Precursor: The bicyclic structure can be modified to create novel ligands for asymmetric synthesis.
• Chemical Biology & Probe Development: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of APIs.

Basic Information

Product Name	Racemic-(1R,4R,5S)-tert-Butyl 5-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2-Carboxylate
CAS No.	198835-03-9
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	tert-Butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate; (±)-(1R,4R,5S)-5-Hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester; 2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-, 1,1-dimethylethyl ester, (1R,4R,5S)-rel-; Bicyclo[2.2.1]heptane-2-carboxylic acid, 5-hydroxy-2-aza-, tert-butyl ester; 2-N-Boc-5-hydroxy-2-azabicyclo[2.2.1]heptane; 5-Hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (racemic); endo-5-Hydroxy-2-aza-norbornane-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of Racemic-(1R,4R,5S)-tert-Butyl 5-Hydroxy-2-Azabicyclo[2.2.1]Heptane-2-Carboxylate adheres to stringent quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for specified enantiomer in racemic mixture)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.