Description

cis-4-Phenylpiperidine-3-Carboxylic Acid, n-Boc Protected is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise stereochemistry and functional group protection in complex molecule assembly. It is primarily utilized in the pharmaceutical and agrochemical industries for the research and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of potential drug candidates, particularly for central nervous system (CNS) targets.
• Peptidomimetics & Constrained Peptides: Used to introduce rigid, phenyl-substituted piperidine scaffolds into peptide backbones to enhance metabolic stability and receptor selectivity.
• Library Synthesis for Drug Discovery: Employed in combinatorial and parallel synthesis to create diverse chemical libraries for high-throughput screening (HTS).
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Catalyst & Ligand Development: Useful precursor for synthesizing novel chiral catalysts and ligands used in asymmetric synthesis.
• Academic & Institutional Research: Supports fundamental studies in medicinal chemistry, organic methodology, and chemical biology.

Basic Information

Product Name	cis-4-Phenylpiperidine-3-Carboxylic Acid, n-Boc Protected
CAS No.	197900-84-8
Molecular Formula	C17H23NO4
Molecular Weight	305.37 g/mol
Synonyms	tert-Butyl (3R,4S)-4-phenyl-3-piperidinecarboxylate; (3R,4S)-1-(tert-Butoxycarbonyl)-4-phenylpiperidine-3-carboxylic Acid; Boc-cis-4-Phenylnipecotic Acid; cis-1-Boc-4-phenylpiperidine-3-carboxylic acid; (3R,4S)-4-Phenyl-1-(tert-butoxycarbonyl)piperidine-3-carboxylic Acid; 1-N-Boc-4-phenyl-cis-pipecolinic acid; 4-Phenyl-1-Boc-pipecolinic acid (cis)
EINECS	Contact for details

Quality Control

Our cis-4-Phenylpiperidine-3-Carboxylic Acid, n-Boc Protected is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for research and process chemistry. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral excess, and spectroscopic data is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.