Description

Parecoxib Na CAS NO 197502-82-2 is the sodium salt of parecoxib, a selective COX-2 inhibitor prodrug. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of finished pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of injectable analgesic and anti-inflammatory medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of injectable parecoxib sodium formulations for acute pain management.
• Analgesic Drug Development: Serves as a key intermediate in R&D for novel non-steroidal anti-inflammatory drugs (NSAIDs) targeting post-operative pain.
• Reference Standard: Used in analytical laboratories as a high-purity chemical reference standard for quality control and method validation (HPLC, LC-MS).
• Clinical Research: Employed in preclinical and clinical studies to investigate pharmacokinetics, efficacy, and safety profiles.
• Formulation Research: Utilized in developing stable lyophilized (freeze-dried) powder formulations for reconstitution.
• Generic Drug Manufacturing: Essential for companies producing generic versions of parecoxib sodium injectable products.

Basic Information

Product Name	Parecoxib Sodium
CAS No.	197502-82-2
Molecular Formula	C19H17N2NaO4S
Molecular Weight	392.40 g/mol
Synonyms	Parecoxib Sodium Salt; SC 69124A; Dynastat (brand name); N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide Sodium Salt; Parecoxib Sodium API; COX-2 Inhibitor Prodrug Sodium Salt; Valdecoxib Prodrug Sodium Salt
EINECS	Contact for details

Quality Control

Our Parecoxib Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting results for assay, related substances, residual solvents, and microbiological limits are available upon request. We adhere to cGMP guidelines to ensure supply chain reliability and product consistency for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual unknown impurity ≤ 0.10% Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.