Description

4-Thiocarbamoyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester CAS NO 196811-66-2 is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and infectious diseases.
• Peptidomimetic Synthesis: Used in the construction of peptidomimetics and constrained peptides due to its functionalized piperazine core and protected carboxylic acid group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the synthesis of new active ingredients for crop protection products.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	4-Thiocarbamoyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	196811-66-2
Molecular Formula	C10H19N3O2S
Molecular Weight	245.34 g/mol
Synonyms	1-Boc-4-thiocarbamoylpiperazine; tert-Butyl 4-thiocarbamoylpiperazine-1-carboxylate; 4-Thiocarbamoylpiperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-thiocarbamoylpiperazine; N-Boc-4-piperazinecarbothioamide; Piperazine-1-carboxylic acid, 4-thiocarbamoyl-, 1,1-dimethylethyl ester; 196811-66-2; Boc-4-Thiocarbamoylpiperazine
EINECS	Contact for details

Quality Control

Our 4-Thiocarbamoyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP-compliant production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.