Description

Pramlintide Acetate is a synthetic analog of the human hormone amylin, formulated as the acetate salt to enhance stability. This compound is critical for advanced pharmaceutical research and development, particularly in the field of metabolic disorders. It is primarily utilized by biotechnology firms, pharmaceutical manufacturers, and research institutions focused on diabetes therapeutics and endocrinology.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of injectable medications for the treatment of type 1 and type 2 diabetes.
• Biomedical Research: Used in preclinical and clinical studies to investigate amylin's role in glucose regulation, satiety, and weight management.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Drug Delivery System Development: Employed in R&D for creating sustained-release formulations and combination therapies.
• Peptide Chemistry Studies: A model compound for studying the synthesis, stability, and pharmacokinetics of therapeutic peptides.

Basic Information

Product Name	Pramlintide Acetate
CAS No.	196078-30-5
Molecular Formula	C171H267N51O53S2 • xC2H4O2
Molecular Weight	~3950.3 g/mol (free base)
Synonyms	Pramlintide; Symlin (brand name); Amylin Analog; AC-137; AC-0137; H-Val-His-Ser-Gln-Asn-Thr-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (acetate salt); 25,28,29-Triprolyl-2-[1-(4-hydroxyphenyl)ethyl]-26,27-secoamylin (human islet amyloid polypeptide) (1-37) acetate
EINECS	Contact for details

Quality Control

Our Pramlintide Acetate is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and biological activity, suitable for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological attributes is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature or refrigerated (2-8°C) as specified. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Water Content (KF)	≤ 8.0%
Acetate Content (IC)	3.0% - 10.0%
Bacterial Endotoxins	< 10 EU/mg
Microbial Enumeration	Meets Ph. Eur. 2.6.12/ USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.