Description

1,2,3,5-Tetrahydro-Benzo[E][1,4]Diazepine-4-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern organic synthesis. This compound serves as a critical building block for the development of novel therapeutic agents, particularly within the central nervous system (CNS) and other specialized drug discovery programs. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzodiazepine and diazepine-based active pharmaceutical ingredients (APIs).
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs), especially for CNS targets.
• Organic Synthesis Building Block: Employed in multi-step synthetic routes to construct complex fused-ring systems due to its reactive carboxylic acid ester and diazepine core.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of investigational and commercial drugs.
• Academic Research: Utilized in university and institutional labs for methodological development and the study of heterocyclic chemistry.

Basic Information

Product Name	1,2,3,5-Tetrahydro-Benzo[E][1,4]Diazepine-4-Carboxylic Acid tert-Butyl Ester
CAS No.	195983-63-2
Molecular Formula	C16H20N2O2
Molecular Weight	272.34 g/mol
Synonyms	tert-Butyl 1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylate; 4H-Benzo[e][1,4]diazepine-4-carboxylic acid, 1,2,3,5-tetrahydro-, 1,1-dimethylethyl ester; 1,2,3,5-Tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxylic acid tert-butyl ester; BOC-Protected Benzo[e]diazepine; tert-Butyl 1,2,3,5-tetrahydrobenzo[e][1,4]diazepine-4-carboxylate
EINECS	Contact for details

Quality Control

Our 1,2,3,5-Tetrahydro-Benzo[E][1,4]Diazepine-4-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality management standards to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.