Description

Apoptolidin is a potent, highly selective mitochondrial F1F0-ATPase inhibitor and a macrolide natural product of significant research interest. Its primary value lies in its ability to induce apoptosis specifically in oncogenically transformed cells, making it a critical tool for studying cancer biology and mitochondrial function. This compound is essential for researchers and pharmaceutical developers in the fields of oncology, biochemistry, and drug discovery, particularly for investigating novel cancer therapeutics and metabolic pathways.

Application

• Biomedical Research: A key pharmacological tool for studying programmed cell death (apoptosis) mechanisms, especially in cancer cell lines.
• Oncology Drug Discovery: Serves as a lead compound or reference standard in the development of novel anti-cancer agents targeting mitochondrial metabolism.
• Mitochondrial Function Studies: Used to investigate the role of the mitochondrial F1F0-ATPase complex in cellular bioenergetics and viability.
• Biochemical Assays: Employed in high-throughput screening and in vitro assays to identify compounds with similar apoptotic activity.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in cell biology and chemical biology.

Basic Information

Product Name	Apoptolidin
CAS No.	194874-06-1
Molecular Formula	C₅₄H₈₂O₁₇
Molecular Weight	1027.22 g/mol
Synonyms	Apoptolidin; Apoptolidin A; Antibiotic C 1027 chromophore; NSC 332295; (1S,2R,3S,4S,5R,6S,7S,8R,9S,10R,11S,12R,13S,14R,15S,16R,17S,18R,19S,20R,21S,22R,23S,24R,25S,26R,27S,28R,29S,30R,31S,32R,33S,34R,35S,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S,50R,51S,52R,53S,54R)-54-[(2R,3R,4S,5S,6R)-3,4-Dihydroxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2,4,6,8,10,12,14,16,18,20,22,24,26,28,30,32,34,36,38,40,42,44,46,48,50,52,54-heptacosahydroxy-3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33,35,37,39,41,43,45,47,49,51,53-hexacosamethyl-1-hexacontanone
EINECS	Contact for details

Quality Control

Our Apoptolidin is produced and handled under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under an inert atmosphere after each use to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.