Description

3-Hydroxycyclobutanecarboxylic Acid is a versatile chiral building block featuring both a carboxylic acid and a hydroxyl group on a strained cyclobutane ring. This unique structure makes it a valuable intermediate for synthesizing complex molecules in pharmaceutical and agrochemical research. It is particularly sought after for developing novel active ingredients and fine-tuning the stereochemistry of target compounds. Researchers and process chemists in advanced organic synthesis rely on this high-purity intermediate for its predictable reactivity and potential in creating new chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting new therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the cyclobutane scaffold can impart unique biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Material Science Research: Investigated as a monomer or building block for novel polymers and advanced materials with specific mechanical or chemical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and labeled compounds for studying biological pathways and mechanisms.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	3-Hydroxycyclobutanecarboxylic Acid
CAS No.	194788-10-8
Molecular Formula	C5H8O3
Molecular Weight	116.12 g/mol
Synonyms	3-Hydroxycyclobutanecarboxylic acid; 3-Hydroxycyclobutane-1-carboxylic acid; Cyclobutane-1-carboxylic acid, 3-hydroxy-; (1r,3r)-3-Hydroxycyclobutanecarboxylic acid; (1s,3s)-3-Hydroxycyclobutanecarboxylic acid; 3-Hydroxy-1-cyclobutanecarboxylic acid; 3-Hydroxycyclobutylcarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxycyclobutanecarboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ISO 9001 standards for reliable sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Chiral Purity (Chiral HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.