Description

(R)-1-Boc-3-Hydroxymethylpiperidine Ethyl Ester is a high-purity chiral piperidine derivative, serving as a critical building block in the synthesis of complex pharmaceutical molecules. Its value lies in its role as a protected intermediate, enabling the stereoselective construction of active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Asymmetric Synthesis: Used in the stereocontrolled construction of complex natural products and bioactive compounds.
• Peptidomimetics Research: Serves as a constrained scaffold for designing novel peptide analogs with enhanced metabolic stability.
• Agrochemical Development: Intermediate in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Building block for creating novel chiral ligands and organocatalysts used in asymmetric catalysis.
• Academic & Contract Research: Valuable reagent for medicinal chemistry programs and process chemistry optimization in R&D laboratories.

Basic Information

Product Name	(R)-1-Boc-3-Hydroxymethylpiperidine Ethyl Ester
CAS No.	194726-40-4
Molecular Formula	C14H27NO4
Molecular Weight	273.37 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperidine-3-carboxylic acid ethyl ester; (R)-Ethyl 1-Boc-3-(hydroxymethyl)piperidine-3-carboxylate; (3R)-1-[(1,1-Dimethylethoxy)carbonyl]-3-(hydroxymethyl)-3-piperidinecarboxylic acid ethyl ester; (R)-1-Boc-3-piperidinemethanol-3-carboxylic acid ethyl ester; tert-Butyl (3R)-3-(hydroxymethyl)-3-(ethoxycarbonyl)piperidine-1-carboxylate; (R)-1-N-Boc-3-hydroxymethylpiperidine-3-ethyl carboxylate
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-3-Hydroxymethylpiperidine Ethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Production adheres to cGMP guidelines where applicable, and all materials are supported by comprehensive analytical data. A Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.