Description

1-(2'-Fluoro)Ethyl-4-(tert-Butyloxycarbonyl)Piperazin-2-One is a high-purity, advanced pharmaceutical intermediate featuring a unique piperazinone scaffold with a fluoroethyl substituent and a Boc-protecting group. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology treatments.

Application

• Key building block in the synthesis of novel piperazine and piperazinone-based active pharmaceutical ingredients (APIs).
• Critical intermediate for medicinal chemistry research, enabling structure-activity relationship (SAR) studies.
• Used in the development of potential drug candidates targeting neurological disorders and psychiatric conditions.
• Employed in the research of oncology therapeutics, where the fluorinated moiety can influence pharmacokinetics.
• Precursor for the synthesis of complex molecules in custom synthesis and contract research organizations (CROs).
• Valuable scaffold for creating libraries of compounds in high-throughput screening for drug discovery.

Basic Information

Product Name	1-(2'-Fluoro)Ethyl-4-(tert-Butyloxycarbonyl)Piperazin-2-One
CAS No.	194351-12-7
Molecular Formula	C11H19FN2O3
Molecular Weight	246.28 g/mol
Synonyms	1-(2-Fluoroethyl)-4-(tert-butoxycarbonyl)piperazin-2-one; 4-Boc-1-(2-fluoroethyl)piperazin-2-one; 1-(2-Fluoroethyl)-4-Boc-piperazin-2-one; tert-Butyl 4-oxo-1-(2-fluoroethyl)piperazine-2-carboxylate; 194351-12-7; 1-(2-Fluoroethyl)-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-2-one
EINECS	Contact for details

Quality Control

Our production of 1-(2'-Fluoro)Ethyl-4-(tert-Butyloxycarbonyl)Piperazin-2-One adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure full traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.