Description

4-(4-Boc-Piperazin-1-Yl)-3-Chloroaniline is a high-purity, protected aniline derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile, functionalized aromatic core with orthogonal protecting groups, enabling the efficient construction of complex pharmacophores. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of new drug candidates, particularly in the areas of kinase inhibitors and other small molecule therapeutics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of biologically active molecules, especially kinase inhibitors and receptor antagonists.
• Chemical Biology Probe Development: Used to create tool compounds for studying cellular signaling pathways and target validation.
• Peptidomimetic Synthesis: Serves as a scaffold for introducing piperazine and aniline motifs into peptide-like structures.
• Agrochemical Research: Intermediate in the development of novel crop protection agents and herbicides.
• Material Science: Building block for specialty polymers and advanced organic electronic materials requiring functionalized aromatic amines.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of APIs and other high-value fine chemicals under cGMP conditions.

Basic Information

Product Name	4-(4-Boc-Piperazin-1-Yl)-3-Chloroaniline
CAS No.	193902-81-7
Molecular Formula	C15H22ClN3O2
Molecular Weight	311.81 g/mol
Synonyms	1-Boc-4-(2-Chloro-4-aminophenyl)piperazine; tert-Butyl 4-(2-chloro-4-aminophenyl)piperazine-1-carboxylate; 3-Chloro-4-(4-(tert-butoxycarbonyl)piperazin-1-yl)aniline; 4-(N-Boc-piperazinyl)-3-chloroaniline; 2-Chloro-4-amino-N-Boc-piperazine; 4-Amino-2-chlorophenylpiperazine-1-carboxylic acid tert-butyl ester; 193902-81-7; 4-(4-Boc-1-piperazinyl)-3-chloroaniline
EINECS	Contact for details

Quality Control

Our 4-(4-Boc-Piperazin-1-Yl)-3-Chloroaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.