Description

n-[[(3R)-1-(Aminoiminomethyl)-3-Piperidinyl]Acetyl]-4-(Phenylethynyl)-L-Phenylalanine Methyl Ester Trifluoroacetate is a high-purity, non-natural amino acid derivative featuring a complex, functionalized structure with a phenylethynyl group and a guanidino-piperidine moiety. This compound matters as a critical advanced pharmaceutical intermediate or research-grade biochemical tool for the development of novel therapeutics, particularly in areas like enzyme inhibition and receptor modulation. It is primarily needed by pharmaceutical R&D laboratories and biotech companies engaged in peptide-mimetic drug discovery and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel peptide-based drug candidates targeting specific enzymes or receptors.
• Medicinal Chemistry Research: Used as a scaffold or precursor for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Protease Inhibitor Development: The guanidino group makes it a potential precursor for designing inhibitors of serine or cysteine proteases.
• Biochemical Probe: Acts as a tool compound in biochemical assays to study protein-protein interactions or cellular signaling pathways.
• Academic Research: Utilized in university and institutional labs for fundamental research in bioorganic chemistry and chemical biology.
• Pre-clinical Development: Employed in the synthesis of compounds for in vitro and in vivo pharmacological evaluation.

Basic Information

Product Name	n-[[(3R)-1-(Aminoiminomethyl)-3-Piperidinyl]Acetyl]-4-(Phenylethynyl)-L-Phenylalanine Methyl Ester Trifluoroacetate
CAS No.	193744-04-6
Molecular Formula	C28H31N4O4 • C2HF3O2
Molecular Weight	~ 614.59 g/mol (Free base: 487.57 g/mol)
Synonyms	4-(Phenylethynyl)-N-[(3R)-1-(aminoiminomethyl)-3-piperidinyl]acetyl]-L-phenylalanine methyl ester TFA salt; (R)-N-((1-(Aminoiminomethyl)piperidin-3-yl)acetyl)-4-(phenylethynyl)-L-phenylalanine methyl ester trifluoroacetate; Methyl (2S)-2-[[(3R)-1-carbamimidoyl-3-piperidyl]acetyl]amino-3-[4-(2-phenylethynyl)phenyl]propanoate trifluoroacetate; CAS 193744-04-6; Advanced Peptidomimetic Intermediate; Guanidino-Piperidine Phenylalanine Derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.