Description

4-n-Cbz-2-Hydroxymethyl-Piperazine is a high-purity, protected piperazine derivative, specifically functionalized with a carboxybenzyl (Cbz) protecting group and a hydroxymethyl side chain. This compound serves as a critical pharmaceutical intermediate and building block in the synthesis of complex molecules, particularly in medicinal chemistry. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing new active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of libraries for high-throughput screening.
• Peptidomimetic Synthesis: The Cbz-protected amine and hydroxymethyl group make it valuable for constructing peptide-like molecules and protease inhibitors.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal complexation.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	4-n-Cbz-2-Hydroxymethyl-Piperazine
CAS No.	191739-40-9
Molecular Formula	C14H20N2O3
Molecular Weight	264.32 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-(hydroxymethyl)piperazine; 1-Cbz-4-(hydroxymethyl)piperazine; 4-(Hydroxymethyl)-1-[(phenylmethoxy)carbonyl]piperazine; 1-N-Carbobenzoxy-4-hydroxymethylpiperazine; 4-(Hydroxymethyl)-N-Cbz-piperazine; 4-(Hydroxymethyl)piperazine-1-carboxylic acid benzyl ester; 1-Cbz-4-piperazinemethanol; Benzyl 4-(hydroxymethyl)piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 4-n-Cbz-2-Hydroxymethyl-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards expected for GMP-grade intermediates used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure containers are sealed after use to prevent exposure to atmospheric moisture. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.