Description

2-Chloro-3-(trifluoromethyl)pyrazine is a high-value, multi-functional heterocyclic building block characterized by its reactive chlorine and electron-withdrawing trifluoromethyl substituents. This compound is essential for introducing the pyrazine core into complex molecular architectures, enabling the synthesis of advanced materials and active pharmaceutical ingredients. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the pyrazine ring contributes to biological activity.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The chloro group is amenable to various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating complex biaryl structures.
• Nucleophilic Aromatic Substitution: Facilitates the introduction of amines, alkoxides, and other nucleophiles into the heterocyclic system for derivative synthesis.
• Fluorinated Compound Library: An important reagent for medicinal chemistry and chemical biology in generating libraries of fluorinated compounds to study metabolic stability and bioavailability.

Basic Information

Product Name	2-Chloro-3-(trifluoromethyl)pyrazine
CAS No.	191340-90-6
Molecular Formula	C5H2ClF3N2
Molecular Weight	182.53 g/mol
Synonyms	2-Chloro-3-(trifluoromethyl)pyrazine; 3-Trifluoromethyl-2-chloropyrazine; 2-Chloro-3-trifluoromethylpyrazine; Pyrazine, 2-chloro-3-(trifluoromethyl)-; 191340-90-6
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-(trifluoromethyl)pyrazine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.