Description

4-[1-(4-Fluoro-Phenyl)-2-Hydroxy-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern synthetic chemistry. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and cardiovascular disorders. It is primarily sought by research institutions and manufacturers in the global pharmaceutical and fine chemical industries for developing new therapeutic agents and process optimization.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially in medicinal chemistry research.
• API Synthesis: Serves as a key building block for constructing complex molecules with piperazine and fluorophenyl pharmacophores, common in CNS and cardiovascular drugs.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial manufacturing of target compounds.
• Chemical Research: Employed in academic and industrial R&D for exploring new chemical entities and reaction methodologies.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Item	Details
Product Name	4-[1-(4-Fluoro-Phenyl)-2-Hydroxy-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	191034-03-4
Molecular Formula	C17H25FN2O3
Molecular Weight	324.39 g/mol
Synonyms	tert-Butyl 4-[1-(4-fluorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate; 1-Boc-4-[2-hydroxy-2-(4-fluorophenyl)ethyl]piperazine; 4-(2-Hydroxy-2-(4-fluorophenyl)ethyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(2-hydroxy-2-(4-fluorophenyl)ethyl)piperazine; CAS 191034-03-4; 1-(tert-Butoxycarbonyl)-4-[2-hydroxy-2-(4-fluorophenyl)ethyl]piperazine
EINECS	Contact for details

Quality Control

Our 4-[1-(4-Fluoro-Phenyl)-2-Hydroxy-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.