Description

Rocaglamide I CAS NO 189322-68-7 is a potent, naturally occurring cyclopenta[b]benzofuran derivative isolated from plants of the genus *Aglaia*. This compound is of significant interest due to its powerful and selective inhibition of eukaryotic translation initiation, making it a valuable tool for biomedical research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies investigating novel cancer therapeutics, antiviral agents, and fundamental cellular processes like protein synthesis.

Application

• Biomedical Research: Used as a highly specific chemical probe to study the mechanism of eukaryotic translation initiation and its role in disease.
• Anticancer Agent Development: Serves as a lead compound and reference standard in the discovery and validation of new oncology drugs targeting protein synthesis in cancer cells.
• Antiviral Research: Investigated for its potential to inhibit the replication of certain viruses by disrupting host cell translation machinery.
• Cell Biology Studies: Employed to induce cellular stress responses and apoptosis, helping to elucidate related signaling pathways.
• Pharmaceutical Reference Standard: Used for quality control, method development, and analytical testing in drug discovery pipelines.
• Biochemical Assays: Acts as a critical reagent in high-throughput screening campaigns to identify new translation inhibitors.

Basic Information

Product Name	Rocaglamide I
CAS No.	189322-68-7
Molecular Formula	C29H31NO7
Molecular Weight	505.56 g/mol
Synonyms	Rocaglamide; (-)-Rocaglamide; Roc-A; Compound 1 (Rocaglamide); AGLA-I; NSC 119305; 1H-Cyclopenta[b]benzofuran-1a,8b(1H)-dicarboxamide, N-[(1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-2-[(1S)-1-hydroxy-1-methylethyl]-6-methoxy-1,3a-epoxycyclopenta[b]benzofuran-5-yl]-2-methyl-, (1aR,8bS)-
EINECS	Contact for details

Quality Control

Every batch of Rocaglamide I is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. We provide comprehensive analytical data including HPLC purity, NMR, and MS confirmation. A Certificate of Analysis (COA) detailing all specifications is supplied with each shipment, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.