Description

Ethanol, 2-[2-[4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazinyl]Ethoxy]-, (R)- is a high-purity, single-enantiomer pharmaceutical intermediate of significant commercial and research importance. This compound is a key chiral building block in the synthesis of advanced active pharmaceutical ingredients (APIs), where its specific stereochemistry is critical for biological activity. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents, particularly within the central nervous system and cardiovascular domains.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Asymmetric Synthesis: Serves as a valuable starting material or reagent in enantioselective synthesis protocols to introduce specific stereocenters.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Potential use in probing specific biological pathways and receptor interactions due to its defined stereochemistry and structural features.

Basic Information

Product Name	Ethanol, 2-[2-[4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazinyl]Ethoxy]-, (R)-
CAS No.	189298-46-2
Molecular Formula	C27H31ClN2O2
Molecular Weight	451.00 g/mol
Synonyms	(R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol; (R)-Hydroxy-PG; (R)-PG-OH; (R)-1-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)-2,3-propanediol (deprotected form related); UNII-Contact for details; A chiral piperazinyl ethanol derivative; (R)-enantiomer of a benzhydryl piperazine ether
EINECS	Contact for details

Quality Control

Our Ethanol, 2-[2-[4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazinyl]Ethoxy]-, (R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent degradation upon prolonged exposure to air.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.