Description

4-(3-Hydroxy-2-Phenyl-Propyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of active pharmaceutical ingredients (APIs) and other fine chemicals, offering a reactive handle for further functionalization. It is primarily needed by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• API Development: Used in research-scale and process chemistry for constructing complex molecular architectures in active pharmaceutical ingredients.
• Chemical Synthesis: Serves as a protected piperazine precursor for introducing nitrogen-containing heterocycles into target molecules.
• Agrochemical Research: Employed in the development of new crop protection agents and pesticides requiring specific amine functionalities.
• Ligand and Catalyst Preparation: Useful for creating specialized ligands for metal catalysis or chiral auxiliaries in asymmetric synthesis.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in medicinal chemistry and synthetic methodology projects.

Basic Information

Product Name	4-(3-Hydroxy-2-Phenyl-Propyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	189298-13-3
Molecular Formula	C18H28N2O3
Molecular Weight	320.43 g/mol
Synonyms	1-Boc-4-(3-hydroxy-2-phenylpropyl)piperazine; tert-Butyl 4-(3-hydroxy-2-phenylpropyl)piperazine-1-carboxylate; 4-(3-Hydroxy-2-phenylpropyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 4-(3-hydroxy-2-phenylpropyl)-1-piperazinecarboxylate; N-Boc-4-(3-hydroxy-2-phenylpropyl)piperazine; Piperazine, 4-(3-hydroxy-2-phenylpropyl)-, 1-(1,1-dimethylethyl) 1-carboxylate; Boc-Piperazine-(3-hydroxy-2-phenylpropyl); 189298-13-3
EINECS	Contact for details

Quality Control

Our 4-(3-Hydroxy-2-Phenyl-Propyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.