Description

Cilengitide CAS NO 188968-51-6 is a potent and selective cyclic pentapeptide antagonist of integrins αvβ3 and αvβ5. This compound is of significant interest in pharmaceutical research and development due to its role in modulating cell adhesion and signaling pathways associated with angiogenesis and tumor growth. It is primarily utilized by researchers and pharmaceutical companies engaged in oncology drug discovery and preclinical studies.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) in the development of anti-cancer therapeutics.
• Angiogenesis Inhibition Studies: For investigating mechanisms of tumor-induced blood vessel formation (angiogenesis) in various cancer models.
• Integrin Biology Research: Used as a specific tool compound to study the role of αvβ3 and αvβ5 integrins in cell migration, proliferation, and survival.
• Preclinical In Vitro & In Vivo Testing: Essential for efficacy and mechanism-of-action studies in cell-based assays and animal models of cancer.
• Formulation Development: Serves as a critical component in the development of novel drug delivery systems for targeted cancer therapy.

Basic Information

Product Name	Cilengitide
CAS No.	188968-51-6
Molecular Formula	C27H40N8O7
Molecular Weight	588.66 g/mol
Synonyms	EMD 121974; Cyclo(-Arg-Gly-Asp-D-Phe-N(Me)Val-); c(RGDf(NMe)V); Cilengitide (EMD 121974); EMD-121974; EMD 121974N; Cyclo(Arg-Gly-Asp-D-Phe-N-methyl-Val); Integrin αvβ3 Antagonist
EINECS	Contact for details

Quality Control

Our Cilengitide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for research and development purposes. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.