Description

Piperazine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester 2-Ethyl Ester is a high-value, protected piperazine derivative serving as a critical chiral building block in advanced organic synthesis. Its primary commercial value lies in providing a sterically hindered, orthogonal protecting group strategy for the piperazine nitrogen atoms, enabling the controlled, sequential synthesis of complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel active pharmaceutical ingredients (APIs), peptide mimetics, and other nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: Key chiral scaffold for the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides with specific chiral centers.
• Ligand and Catalyst Development: Precursor for creating chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Chemical Synthesis: Employed in contract research and manufacturing (CRO/CMO) for bespoke, multi-step synthetic routes.
• Academic & Industrial R&D: Fundamental reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Piperazine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester 2-Ethyl Ester
CAS No.	188567-82-0
Molecular Formula	C₁₃H₂₄N₂O₄
Molecular Weight	272.34 g/mol
Synonyms	1-Boc-2-Ethyl Piperazine-1,2-dicarboxylate; (2R)-1-[(1,1-Dimethylethoxy)carbonyl]-2-[(ethoxycarbonyl)amino]piperazine; 1-N-Boc-2-N-ethoxycarbonylpiperazine; 1-tert-Butyl 2-Ethyl Piperazine-1,2-dicarboxylate; tert-Butyl 2-(ethoxycarbonyl)piperazine-1-carboxylate; BOC-Pip(EEt)-OH (protected form); Piperazine-1,2-dicarboxylic acid, 1-(1,1-dimethylethyl) 2-ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Piperazine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester 2-Ethyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral purity assessment, to ensure compliance with exacting R&D and cGMP standards for advanced intermediates. Comprehensive Certificates of Analysis (COA) with full chromatographic data (HPLC, GC) and spectroscopic characterization are provided to guarantee traceability, identity, and purity for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.