Description

Cholesteryl n-(Trimethyl-Ammonioethyl)Carbamate Chloride is a high-purity, synthetic cationic lipid derivative of cholesterol. This compound is valued for its unique amphiphilic structure, which enables it to form stable complexes with nucleic acids and other biomolecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for advanced drug delivery applications, particularly in the development of non-viral gene therapy vectors and lipid nanoparticles.

Application

• Lipid Nanoparticle (LNP) Formulation: A key cationic lipid component for constructing stable LNPs used in mRNA vaccine and therapeutic delivery systems.
• Gene Therapy Research: Serves as a critical transfection reagent and structural element in non-viral gene delivery vectors, such as lipoplexes.
• Drug Delivery Systems: Employed to create targeted and sustained-release formulations for hydrophobic and nucleic acid-based active pharmaceutical ingredients (APIs).
• Biomimetic Membrane Studies: Used in research to model and study the properties of cationic lipid membranes and their interactions with cellular components.
• Diagnostic Reagent Development: Acts as a functional material in the design of diagnostic assays and imaging contrast agents.

Basic Information

Product Name	Cholesteryl n-(Trimethyl-Ammonioethyl)Carbamate Chloride
CAS No.	188022-80-2
Molecular Formula	C₃₃H₅₉ClN₂O₂
Molecular Weight	551.29 g/mol
Synonyms	Cholesteryl 3-[(2-Trimethylammonio)ethyl]carbamate chloride; Chol-TMA; 3β-[[2-(Trimethylammonio)ethoxy]carbonyl]cholest-5-ene chloride; Cationic cholesterol derivative; Trimethyl(2-{[(3β)-cholest-5-en-3-yloxy]carbonyl}amino)ethylammonium chloride; N-Cholesteryloxycarbonyl-2-aminoethyltrimethylammonium chloride; Cholesteryl carbamate TMA salt
EINECS	Contact for details

Quality Control

Our Cholesteryl n-(Trimethyl-Ammonioethyl)Carbamate Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.